I've seen similar posts like this before and I didn't mind them until I have finally confirmed this was my case as well.
I have a really beefy computer so i'm sure it's not my hardware issue.
I do have 3 displays (24" LCD x 3)
What happens to me is that, at first booth my PC is super quick. I take screenshots (custom region) a lot, nature of my work, and everything is snappy. But over the course of hours I will notice my PC slowing down, windows are getting more and more laggy, will notice screenshots taking a bit slower to aquire (like minimal but i know it aint snappy as it should) etc
I notice lots of apps/windows become sluggish (telegram, skype, etc) like they get all sticky and not snappy.
I've always thought something in my PC was causing it but nothing out of the ordinary on the resource manager.
So I have no choice but to reboot. After reboot all is well, until a few hours later.
TODAY I decided to reboot PC and not turn on Display Fusion... Many hours of working I can already say my PC has not lagged one bit!! I do the same thing day in and day out and the only difference today is that DISPLAY FUSION is OFF!
Wow.. all this time it was DF causing my PC slow down!

I've got the latest DF version installed.
I love DF (paid for it) and it's painful not to have it.
Has anyone ever figured this out yet?
Regards