Running Win 10. Monitor configuration is 2 - 1 and 3 is directly below the two in the center. Normal cursor movement is left to right and I have to move through monitor 1 in order to get from 2 to 3. I'd like to be able to go directly from 2 to 3 - is there a way to accomplish that?

Right click on your desktop and choose Display Settings then change the order of the displays by dragging and dropping the display order. Click Apply to test.
I think if you change the displays to 3 - 2 - 1 you should get the desired effect you want but you will have to go out of 1 on the right hand side to get to 2.
Make sure you click Apply for each order you want to try or you wont see any change.

Well, that wasn't what I wanted, but it got me looking at the arrangement again and I tried the simple solution which I thought I had previously tried. I probably neglected hitting the Apply button before (old age problem). So, here's what I now have, and it works. I can move the cursor from any of the three monitors to any other with a logical move across physically adjacent borders.

Glad it works for you

Got a new monitor, and of course it's messed up my arrangement. I have 3-1-2 left to right in a row... and i want the cursor to also go left to right. Can't work out how to do it. Cant change monitors because of their connections. 3 and 1 both hdmi so on different cards, and 2 is on dvi on the first card. Help please.