This is my physical monitor layout.
Monitor #2 = HP E231i, Portrait, 1080 x 1920
Monitor #4 = Samsung C49J89x, Landscape, 3840 x 1080, Primary Display
Monitor #3 = HP E231i, Landscape, 1080 x 1920
Monitor #1 = HP E231i, Landscape, 1080 x 1920
Pertaining to the above red circle, it is extremely difficult to move the mouse pointer between those two monitors. It’s like there’s some sort of resistant block that I have to “break through” with the mouse, hitting multiple times before the pointer actually passes through from Monitor #3 to Monitor #1. In reverse (from Monitor #1 to Monitor #3), there is no issue.