Could you provide some more details on what you're looking to do? E.g. what are you wanting to happen when the monitor configuration change is detected?

Thanks!

Does each window have its own page unique page title? And do they stay on those pages? If so, you could save the layout as a Window Position Profile, then save the monitor configuration as a Monitor Profile, and assign the Window Position Profile to the Monitor Profile. (new record for using the word "profile" in the same paragraph )

More info on Window Position Profiles here: https://www.displayfusion.com/HelpGuide/WindowPositionProfiles/