Can you open up the DisplayFusion settings window and head to the compatibility tab, add in the game, and check "Disable Application Hooks" and see if that fixes it?
It happened again, so I tested with the application setting like you said and it doesn't lock up but fps definitely gets hit hard losing 40-60%, no fps loss at 500 hz
Seems ok, still not 100% on insider and the testing environment tbh, insider updates and now even at 500 hz there is *some* fps loss even with minimum side apps running.