I am not 100% certain but I think the problem started happening after I "upgraded" from 23H2 to 24H2. When I change the monitor profile from i.e. 4 monitors to a profile with 6 monitors, Displayfusion cannot activate these mobnitors any more. I have to extend the desktop to these monitors manually through the Windows Display Settings and then activate the profile on Displayfusion for finetuning and splits. Are you aware of this issue, or am I the only one?

They are all extended

Thank you for the reply, I just found the time to reproduce the problem:
it starts at around 17:41.
So I start with my profile with 6 monitors, ome of them split and Monitor Nr1, the laptop monitor is disconnected
I switch to the profile with 4 monitors and then to the one with 2.
When I switch back to the profile with 6 monitors, the laptop monitor Nr 1 gets connected, takes the place of monitor 2 and monitors 2 and 3 are disconnected. Displayfusion thinks the profile is loaded. I try to change/disable monitor 1 and then activate monitor 3 and 2 and in the end the profile gets back, but till then it is impossible to do it through the normal profiles.

Hope it helps.

I was away from the desktop setup. I cleaned up the profiles and saved them again, the issue remains as in the log I sent. The monitors cannot re-activate from DP. I have to go to the Window Display Settings to connect/extend and then I can call the DP profile.

Another debug file, starting in the beginning at 10:04. From the Profile from 4 similar Dell monitors to the profile to 6 monitors (2 additional portrait ones, on in 4k and the other in 1200p), DP indicated the profile change taking place, but the monitors remain inactive. The profile change to 2 similar Dell monitors. Then back to the 6 monitors, the monitors activate, but also the laptop monitor, 6 in total, monitors are messed up, I have to manually disconnect laptop monitor to get the profile back. Hope this helps

11 days ago, problem always persists. The only possible source is that the 2 monitors that cannot be re-connected from Displayfusion are in Portrait mode. One is a 4k the 2nd is a 1200p monitor, both in in potrait mode. If I load a profile with one of them in landscape instead of portrait it works for the one in landscape, not for the one in portrait. I wonder if I should downgrade to a previous version

"Downgraded" to the
DisplayFusion 11.0.5 (Dec 24, 2024) and everything works like a charm, The problem had nothing to do with Windows 24H2 and everything with your newer versions

Thank you, I will try over the weekend when I find time

I tried and it does not work, as I explained it fails to activate the monitors that are in portrait mode, if I load them in a profile in landscape they load. I will try to do the previous versions but most probably I will revert to the December version that works well

Already the 11.0.6 Beta 6 broke it, same behavior, shows the profile to be loaded but monitors in portrait fail to connect. I reverted back to the 11.0.5

The link is not working more but I retrieved the beta from my recycle bin. I send you 2 debug files, one with the old version where things behave correcty and one as you asked with the beta.
Below are the time stamps:

DISPLAYFUSION DEBUG LOG
Ver.11.0.5
11:33:00 From 6 monitors (2 portrait +4 landscape) to 4 (all landscape)
11:34:36 Back to 6 monitor profile
Ver . 11.2. (Beta1)
11:41:58 - 11:42:44 From 6 monitors (2 portrait +4 landscape) to 4 (all landscape)
11:43:12- 11:43:22: Attempt to get back to 6 monitor profile, it shows that it changed but monitors remain disconnected and the profile remains the same
11:44:38 -11:45:34 Change to a profile where one of the portrait monitors switches to landscape (5 monitors in landscape and one in portrait), the one in portrait remains disconnected.
Since one of the monitors (the portrait one) is not activated the profile is not correct and it does not show activated in Dislayfusion profiles
11:48:10 Extended manually the missing display from windows and from the Windows both monitors that were in portrait are back in portrait
11:49:42 DIsplayfusion finds a similar to the initial profile but without the splits
11:50:11 Profile loaded on DP with the splits

As I have already explained and probably shows in the previous logs I had sent the problem is clearly linked to activating back monitors that in the profile are in portrait mode.

Hope all that helps, I spent 30 minutes of my work time.

I have no clue how to install/run this tool.
EDIT: As I explained when I activate the monitors from Windows, then Displayfusion can find them and profiles are activated again.

Still not working the naming of the file is the same as the last one, I hope I did not waste my time trying the wrong file

Here you are: