I am not 100% certain but I think the problem started happening after I "upgraded" from 23H2 to 24H2. When I change the monitor profile from i.e. 4 monitors to a profile with 6 monitors, Displayfusion cannot activate these mobnitors any more. I have to extend the desktop to these monitors manually through the Windows Display Settings and then activate the profile on Displayfusion for finetuning and splits. Are you aware of this issue, or am I the only one?

They are all extended

Thank you for the reply, I just found the time to reproduce the problem:
it starts at around 17:41.
So I start with my profile with 6 monitors, ome of them split and Monitor Nr1, the laptop monitor is disconnected
I switch to the profile with 4 monitors and then to the one with 2.
When I switch back to the profile with 6 monitors, the laptop monitor Nr 1 gets connected, takes the place of monitor 2 and monitors 2 and 3 are disconnected. Displayfusion thinks the profile is loaded. I try to change/disable monitor 1 and then activate monitor 3 and 2 and in the end the profile gets back, but till then it is impossible to do it through the normal profiles.

Hope it helps.

I was away from the desktop setup. I cleaned up the profiles and saved them again, the issue remains as in the log I sent. The monitors cannot re-activate from DP. I have to go to the Window Display Settings to connect/extend and then I can call the DP profile.

Another debug file, starting in the beginning at 10:04. From the Profile from 4 similar Dell monitors to the profile to 6 monitors (2 additional portrait ones, on in 4k and the other in 1200p), DP indicated the profile change taking place, but the monitors remain inactive. The profile change to 2 similar Dell monitors. Then back to the 6 monitors, the monitors activate, but also the laptop monitor, 6 in total, monitors are messed up, I have to manually disconnect laptop monitor to get the profile back. Hope this helps